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Inherently, the initial phase of the healing process is considered to be one of the critical determinants of the healing outcome (Kolar et al. 2010).
For a successful healing outcome, the spatial and temporal interplay of these different components has to be well orchestrated.
Controlling the pore size of scaffolds is one technique that shows promise in decreasing pro-inflammatory macrophage presence and improving the healing outcome.
This highlights the central role of the early inflammatory reaction in the haematoma in determining the healing outcome as a crossroad towards regeneration or scar formation (Harty et al. 2003).
Long bone fractures stabilized with thin intramedullary nails commonly used for unreamed intramedullary nailing might be very flexible in shear direction and therefore critical for the fracture healing outcome.
The aim of this study was to evaluate the healing outcome after periapical surgery with an ultrasonic cleaning technique in conjunction with the use of either of 2 different retrograde root-filling materials in teeth with apical periodontitis.
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Strategies to improve wound healing outcomes therefore require methods to limit fibrosis.
Though promising, no single treatment currently offers effective and definitive healing outcomes.
Evidence shows that smaller incisions with modest manipulation of soft tissue do not affect postoperative healing outcomes.
Long-term treatment has been associated with significant adverse effects and comorbidity and no treatment protocol has demonstrated enduring healing outcomes [83, 92, 93].
Delayed or non-healing of bone is a major clinical problem, with around 10% of fracture patients suffering from unsatisfying healing outcomes.
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