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Information about headache was collected on average 4.0 years (95% CI 3.7 4.2 years) after randomization.
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Full medical history, physical examination, electrocardiography (ECG), vital signs and baseline headache were collected at arrival.
The characteristics of headache were collected by a questionnaire, which was administered by one of the authors.
All headache information was collected by three neurologists through face-to-face interviews.
Information concerning headache and seizures was collected from 1,795 headache patients under 18 years of age consecutively diagnosed at the Headache Center of the Department of Pediatrics of the University of Padua between 1995 and 2008 (Table 1).
A total of 5248 residents aged 60 years and older were visited from 2014 to 2015, unannounced, and basic sociodemographic and headache diagnostic information was collected via a questionnaire.
Also, even though the study was designed as a prospective study, information about migrainous headache before pregnancy was collected retrospectively, thus making recall bias a possibility.
Headache-day severity was collected on a daily basis via the patient diary and assessed every 4 weeks.
Additional information including the migraine history (e.g., onset age, frequency and duration of attacks, headache characteristic, and the pain intensity (evaluated with the visual analogue scale (VAS))) and the impact of headache (evaluated with the Migraine Disability Assessment Scale (MIDAS) [29] and Headache Impact Test (HIT -6 [30]) was collected in tHIT -6nes wash migraine.
The family history of headache and treatment for headache among parents and siblings enumerated individually was collected at two of the interviews.
All data was collected prospectively with the use of headache diaries.
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