The other study, primarily focussing on the role of C. burnetii in CFS, reports improvement in performance status, a decreased mean headache score, and a decrease in mean weekly temperature after treatment [ 21].
The primary efficacy measure was headache relief (a decrease in headache from moderate or severe to none or mild) at 2 h.
In the triptan development programmes, recurrence has been defined as headache relief (a decrease in headache from moderate or severe to mild or none) after 2 h and recurrence of moderate or severe headache within 24 h.
It should be noted, however, that headache relief (a decrease in headache from moderate or severe to none or mild) was first measured after 4 h because naratriptan is generally held to be a slow-acting triptan [5].
37 38 Headache relief (a decrease in headache from severe or moderate to none or mild within 2 h, before any rescue medication).
The chronic pain group with the greatest improvement at 6 months was the Chronic Non Spinal Pain group (joint pain, headache, fibromyalgia) with a decrease in depression and anxiety and improvement in health related quality of life at six months' follow-up (Cohen's d=0.74, 0.53, and 0.69, respectively); the benefit persisted over 24 months.
Abildso et al 32 and Hunt et al 9 reported that many participants experienced benefits after participating in the programme, such as better quality sleep, decreased pain, improved blood pressure, improved cholesterol, loss of leg neuralgia and a decrease in headaches associated with discontinuing some of the medications taken for obesity-related conditions.
But on average they experienced 21 fewer hours of pain during the study period than those in the placebo group, and a decrease in the intensity of their headaches.
Integrated headache care led to a decrease in anxiety and depression at 12-month follow-up.
(+1/+0) Is "headache relief" (percentage of patients with a decrease in headache from severe or moderate to none or mild within 2 h before any rescue medication) used as a measure of efficacy?
