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Wissenbach recognized that many entrepreneurs are challenged by problems that are, in reality, easy to solve -- if they just applied some structure.
In the Scottish Highlands, popular education was challenged by problems of distance and physical isolation, as well as teachers' and ministers' limited knowledge of Scottish Gaelic, the primary local language.
Little known fact about Thomas Edison: Whenever he was challenged by a difficult problem, he would nap under his desk or on a work bench while holding two steel balls in both hands.
When he was challenged by Klingons, he had no problem getting back in their faces and swearing at them.
However, becoming a reality and readily availability of edible vaccine is challenged by many problems of technical, regulatory, and nonscientific issues, which should be ruled out and rectified.
The performance of ITER Main Chamber H-alpha (and Visible Light) Spectroscopy diagnostics is challenged by the problem of separating the Balmer-alpha light emitted in the scrape-off-layer (SOL) in the main chamber from the much more intense divertor stray light (DSL) − the light emitted in the divertor in the same spectral line and reflected by the all-metal first wall (FW).
The Abstinence, Be Faithful and use a Condom prevention methodology is challenged by supply chain problems, anti-condom sentiments by some religious groups, and limited incorporation of cultural concepts of sex in HIV prevention [ 3, 15].
The performance of the proposed hybrid algorithm for solving both single and multi-objective optimization problems is challenged by using of some well-known benchmark problems.
However, health financing is challenged by a number of problems such as public under-funding, high user fees and informal payments, causing the poor to be deprived of health care [ 2].
In fact, the combination of WMSN and MCC for complex event monitoring is challenged by a series of special technical problems.
The traditional focus on strict statistical analysis of the tiny fragments of reality that we are able to measure is challenged by ethical concern from a societal problem solving perspective and demands critical qualitative reflection on the ambitions and responsibilities of environment and health science.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com