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19, 20 The ability of the patients to serve as their own controls to compare rates of HE breakthrough events, HE-related hospitalisations and AEs before and after initiation of rifaximin therapy is a strength of this study.
The temporal profile of HE breakthrough events across the 82 patients could be described with four categories: (i) HE breakthrough episode occurrence in the RCT only: n = 26; (ii) occurrence in both the RCT and OLM study: n = 13; (iii) occurrence in the OLM study only: n = 1; and (iv) no occurrences in the RCT or OLM study: n = 42.
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