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The proportional hazard hypothesis could not be rejected as well with the other therapy encodings.
The proportional hazard hypothesis was visually checked with log log curves.
The proportional hazard hypothesis was verified based on the correlation between Schoenfeld residuals and time.
In this study, we mainly tested whether the mutational hazard hypothesis could be used to explain the pattern of intron loss.
Ultimately, the results presented in this study go against the documented trend of πsilent positively correlating with genome compactness, and thus challenge the central premise of the mutational hazard hypothesis.
Similar(55)
The latter observation presents a challenge for the mutational-hazard hypothesis [13], which posits that mRNA editing should not occur in lineages with an elevated mutation rate.
Tests designed to detect increasing hazard ratio against the proportional hazards hypothesis are generally consistent for other alternatives also.
We suggest that the mutational-hazard hypothesis does not necessarily conflict with such correlations.
Furthermore, we suggest that the mutational-hazard hypothesis might underlie the reported correlations between genome size and phenotypes.
This hypothesis and the mutational-hazard hypothesis both predict that introns with higher mutation rates would be preferentially lost.
According to the mutational-hazard hypothesis, introns with higher mutation rates are more likely to be eliminated.
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