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This "signal" is the early peak of hazard for relapse that follows surgery within 12 to 24 months, whereas the near constant hazard thereafter might be the "echo" of the natural history of breast cancer left unperturbed by surgical interference.
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The main differences across the two treatments appear to be linked to the yearly hazards for relapse and discontinuation, which are lower with OLAI.
Cox univariate regression analysis shows that hTERT-positive patients had a high and statistically significant risk for relapse (hazard ratio (HR)=2.24, P=0.038, respectively) (Table 5).
The Cox's proportional hazard model was used to obtain hazard ratios for relapse or death.
In addition, many of the newer studies perform analyses that use time-to-new-episode or time-to-new-rehospitalization or hazard ratios for relapse as the main outcome measure for long-term prophylactic effectiveness (Bowden et al. 2003; Tohen et al. 2005; Viguera et al. 2001; Geddes et al. 2010; Suppes et al. 2009).
We also assumed that neither the hazard rate for relapse on AIs nor the tumor characteristics were affected by metabolizer status and CYP2D6 genotype.
We examined the hazard function for relapse.
Up to now, investigators have examined the hazard ratio for relapse every 6 12 months.
The estimated hazard ratio for relapse on placebo compared to escitalopram was 5.4 for young-old patients and 3.2 for old-old patients.
An increase in density of CD4+ cells also decreased the hazard ratio for relapse of disease, but it was only borderline significant for intratumoural cells.
There certainly is an increase in the hazard rate for relapse in the first 3 years after treatment (Hussain et al, 1995; Saphner et al, 1996).
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