It also demonstrates more generally how potential perturbation of a causal pathway through, for example, drug treatment targeting one trait could have unexpected effects on another, even when there is no clear evidence that these traits are associated clinically or epidemiologically a problem often encountered in drug development.
But trauma can have unexpected effects on how victims come across".
In conclusion, this study points out that high-frequency capacitively coupled RF nitrogen plasma treatment processes have unexpected effects on structural ordering/disordering and some interfacial properties of the unsized HS PAN-based carbon fiber.
Although such retractions and corrections appear to be relatively easy and costless ways to fix the erroneous disclosure, our results generally show that both actions have unexpected effects on investor judgment.
In this hypothetical situation, the expression of MarT in S. Typhi could have unexpected effects on several pathogenic associated phenotypes, probably decreasing the virulence of this human restricted serovar.
For example, the abundant clam beds found here are typically found in enclosed lagoons around the Central Pacific [30], and opening the lagoon would likely have unexpected effects on the clam population in particular.
Fourth, the sham treatment itself may have had unexpected effects on the treatment of constipation rather than no effect at all.
However, the picture is likely much more complex and methylation changes outside promoter regions may have unexpected effects on gene expression [ 28, 29].
The targeted pharmacologic inhibition of TLR4 in the clinical setting of myocardial ischemia and reperfusion could initially lead to a smaller infarct, but an altered inflammatory response could have unexpected effects on cardiac function and long term infarct healing.
Surprisingly, Dkk-1 also had unexpected effects on MOSJ cells in that it increased proliferation and resistance to metabolic stress in vitro and caused the formation of larger and more destructive tumors than controls upon orthotopic implantation.
