Sentence examples for having common downstream from inspiring English sources
At the receptor level, other RTKs (receptor tyrosine kinases) having common downstream targets of EGFR/HER2 may become involved in cross-talk with EGFR/HER2 signaling pathways.
The above simulation has relevance for the case of pathways which are costimulated, and which have common downstream targets.
Recently it was reported that the mouse Txnrd1 gene is alternatively spliced, producing three isoforms of mouse Txnrd1 mRNA that vary in their 5' sequences but have common downstream sequences [ 17].
Although the HOXA3 paralog is functionally similar to HOXD3 with respect to promotion of cell migration, these transcription factors do not have common downstream target genes [ 63]. β 3 integrin mRNA levels are increased in endometrial adenocarcinoma cells transfected with a HOXA10 expression vector and are decreased in the cells treated with a HOXA10 antisense construct [ 54].
Although the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways have distinct effects on cell proliferation, they have many common downstream targets that may be able to function in promoting survival in the absence of the corresponding functional pathway.
Also, these genes had a common downstream gene, Rac, which might be a potential target molecule for developing novel treatments for TNBC.
The SphK1 isoform has two major subtypes, SphK1a and SphK1b, and emerging evidence indicates that SphK1a and SphK1b have common and differing interacting partners [ 41] and, through such interactions, each subtype is able to influence diverse downstream signalling pathways [ 42].
They have common interests.
Our data further show that GTL1 and RSL4 regulate each other, as well as a set of common downstream genes, many of which have previously been implicated in root hair growth.
Therefore, eugenol-related down-regulation of NF-κB and β-catenin and their common downstream target cyclin D1 could have a great inhibitory effect on breast cancer growth.
