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The discrepancies between these observed effects may be due to APAP having a limited effect on some cell populations or conversely affecting only specific genes or proteins.
Generally, MTX treatment inhibits proliferation of rapidly dividing cancer cells without having a limited effect on the proliferation of differentiated cells.
On the other hand, a single mutation in a critical gene may have profound biological effects despite having a limited effect on the total gene expression profile.
Rescuing cardiac muscle (and having a limited effect in skeletal muscle), the drug enables much longer survival of infantile-onset patients [ 6- 8] but leaves them with skeletal muscle myopathy, often more severe than in late-onset cases [ 9- 11].
Overall, despite Pi starvation having a limited effect upon DNA methylation in Arabidopsis compared to rice, with only 2 PSI DMRs identified, the location of these PSI DMRs appears to be conserved, with hypermethylated regions overlapping with specific TEs that are close to highly induced PSI genes.
Similar(54)
Even social class had a limited effect.
The union campaign has had a limited effect on Labor Ready, Mr. King said.
"Any uncertainties in the runup to the referendum seem to have had a limited effect.
A ban would have a limited effect on gun-industry profits.
"It probably had a limited effect, if any effect, on the outcome on any game," he said.
Sales and press coverage have a limited effect on who the bookies think will win, Adams explains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com