Sentence examples for have undergone large changes from inspiring English sources
Substrate abbreviations are as defined in the legend to Figure 2. We also examined whether P450 variants with mutations near the substrate binding pocket were more likely to have undergone large changes in their activities.
This can be a very strong assumption when dealing with emerging economies, since they have undergone large structural changes that are unlikely to be repeated.
XRCC4 proteins appear to conform to such a pattern, and we note that the unusually large divergence of S. pombe Xrc4 is accompanied by a lack of conservation in the inter-BRCT linker region of S. pombe Lig4, suggesting that the interaction interface between Xrc4 and Lig4 may have undergone large but compensatory changes.
The researchers looked in igneous rocks of Western Australia, particularly in those that didn't show signs of having undergone large-scale metamorphic changes deep within Earth.
Therefore, variants with mutations near the substrate binding pocket have a higher probability of undergoing large changes in activity than all other variants, although many variants without mutations near the pocket also underwent substantial activity changes.
We conducted extensive molecular evolutionary analyses on snake mitochondrial proteins and discovered multiple lines of evidence suggesting that the proteins at the core of aerobic metabolism in snakes have undergone remarkably large episodic bursts of adaptive change.
