The phrase 'have substantial differences' is correct and can be used in written English.
You can use it when you want to indicate that two or more things are quite different from one another. For example: "The cultures of India and Japan have substantial differences."
HPV16, 18, 31, 33, 45, 52, and 58 together contributed 73.9% of CIN2+lesions and all high-risk types contributed 86.9%.In summary, the different oncogenic HPV types have substantial differences in their oncogenic potential.
It's all right to disagree sometimes, to have substantial differences.
According to polls taken in the past four years, half of all evangelicals have substantial differences with the religious right.
We will have still have substantial differences of view about many areas of policy and regional politics.
While the House and Senate bills have substantial differences, both cut taxes, on average, for many millionaires and billionaires.
Beyond the health care plan, ABC and the union have substantial differences on issues like temporary workers, control of new technology and pension contributions.
According to the analysis and discussion in the previous section, we observe that the distributions of some important molecular properties for drug-like and non-drug-like molecules do not have substantial difference when the two datasets have similar MW distributions.
Only unaffected carriers over the age of 60 were used for gene array experiments, since they had the least probability of later developing later disease, and would still have substantial difference in age of onset if they did harbor occult disease.
A comparison of the foF2 variations for the two meridians shows that even with a relatively small difference of longitudes (45°), the recovery phase has substantial differences of ionospheric disturbances.
