While tests for embryonic mortality are straightforward, it is much more difficult to test the role of particular genes on complex adult phenotypes as those may have small effects [ 42] or their effects may depend on unknown environmental components.
This is more likely to occur when the absolute cost of hemizygosity is small (long pathways and weak selection), because increasing wild-type enzyme dose will have small effects on flux and small deleterious effects on fitness.
A growing body of research on the distribution of fitness effects among beneficial mutations suggests that most have small effects and a few have much larger effects on fitness [ 1, 2].
And (v) K e is a conserved estimate of K because those pleiotropy components that have small effects on fitness would be effectively removed by the estimation procedure.
For instance: is it the case that most beneficial mutations have small effects — and how often do beneficial mutations with large effects happen?
When treatments have small effects and studies have small numbers, a clinically significant effect of treatment may be missed [ 29].
Participation in the school-based prevention programme 'Eigenständig werden 5+6' may have small effects on smoking behaviour and attitudes and a moderate effect on smoking-related knowledge.
This might impede the detection and functional analysis of many other genes and alleles that by themselves have small effects on phenotypes, but together might have a large effect.
From this analysis, we cannot conclude that deletions in these regions do not have effects; they may well have small effects.
After comparing the results under scenarios I, V, and VI, we found that the level of treatment effects and depth of reads have small effects for all of the methods under reasonable sample size.
The policies have small effects on largemouth bass size and property prices on most lakes, although the effects are more pronounced on some.
