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Discover LudwigSuggestions(5)
"have significantly changed" is correct and usable in written English.
It is most often used to describe the amount of change that has happened over a period of time. For example: "In the past ten years, the demographics of our city have significantly changed."
Exact(60)
Tablets in particular have significantly changed the way people shop.
"I do not think we have significantly changed the psychology of the shopper," he said.
Comfort said: "In the past two years we have significantly changed the culture of the organisation.
U.S.-Russian relationships have significantly changed since the terrorist attacks on September 11.
But none of the Republicans' efforts have significantly changed Mr. Spitzer's lead.
US FDA and European (EMA) regulations have significantly changed the pediatric drug development process.
Long-term human-induced impacts have significantly changed the Amazonian landscape.
But some professors say they have significantly changed their teaching practices to accommodate the students.
Both proposals would have significantly changed the building; both are thoughtful attempts to fuse old and new without compromising either.
Land reform, industrialization, and depopulation have significantly changed the character of many rural districts.
"I don't think a large consumer campaign would have significantly changed the outcome for Myspace," he said.
More suggestions(13)
have significantly challenged
have noticeably changed
have vastly changed
have significantly altered
have significantly modified
have considerably changed
have markedly changed
have dramatically changed
have significantly changing
have greatly changed
have significantly outperformed
have significantly improved
have significantly revised
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com