This is unnecessary treatment that can have significant side effects".
"If some of these drugs have significant side effects, then we all have to take more time," said Dr. Gross, chairman of internal medicine at Hackensack University Medical Center.
But doctors have debated whether all patients should be treated, because the disease often progresses slowly, not all patients incur severe liver damage, and because the drugs are expensive, have significant side effects and do not always work.
The rise and fall -- and possible resurrection -- of Lotronex highlights a longstanding problem facing the F.D.A. and pharmaceutical companies: what to do when a useful drug turns out to have significant side effects, particularly when the problems do not become apparent until after the drug is approved.
Rather, they have significant side lobes.
The conventional medications for depression, however, often have significant side effects.
Treatment regimens combining cyclophosphamide with steroids preserve kidney function but have significant side effects.
However, some patients do not respond to mexiletine or have significant side effects limiting its use.
Statins have significant side effects in some people and don't always reduce cholesterol enough in others.
However, some schemes, especially those that intervene in the ecological system, are certain to have significant side effects.
Many treatment options exist for CLBP, but most have limited effectiveness and some have significant side effects.
