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In line with this, decreased phosphorylation of SMAD3, an indication of decreased signalling activity, has been reported during OA progression of murine models of OA [ 44, 45], and SMAD3 knockout mice have shown to develop OA-like features in their joints [ 46].
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Dynamic parameters have been developed and have shown to be accurate [4 6].
While orthopedic trauma patients have been shown to develop greater rates of adverse events, no study has examined septic complications in isolation from other less serious conditions.
It has deleterious effects on patients and joint deformities and disease progression have been shown to develop over time [ 1– 4].
In particular, IL-13 has been implicated in the pathogenesis of MCD, as transgenic rats overexpressing this cytokine have been shown to develop proteinuria.
These animals have been shown to develop normally; the expressed antibody repertoire largely mirrors that in humans.
ES cell-derived neural precursors have been shown to develop into morphologically mature neurons and glia when grafted into brain and spinal cord.
Cytochromes c3 are polyheme c-type cytochromes characterized by low redox potentials, that have been shown to develop metal-reductase activity.
While large doses of the chemical, are known to cause nerve damage in people, acrylamide is deemed "a probable" human carcinogen by the Environmental Protection Agency because only rodents have been shown to develop tumors from exposure to it.
However, IFNs are species-specific and antibodies have been shown to develop in response to the high rHuIFN-α doses necessary for an effective therapy.
In addition, up to 41% of EVAR patients have been shown to develop post-procedural complications, with 20% subsequently requiring fluoroscopically based radiological re-intervention [1].
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