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Phase II studies in HNSCC using bevacizumab in combination with pemetrexed, erlotinib or cetuximab have shown response rates of 15 30%.
A subset of GISTs that lack KIT mutation harbour PDGFRA mutations and have shown response to imatinib therapy as well (Heinrich et al, 2003).
Recent studies have shown response rates of 62.5% with docetaxel plus cisplatin (Lin et al, 2007) and 50% with docetaxel plus epirubicin (Hainsworth et al, 2006).
Previous studies with peptide nanotubes and peptide derivative hydrogels have shown response to various types of treatment, whether changing stability or degrading entirely [ 8- 10].
Given as first-line treatment to chemo-naïve patients, anthracyclines have shown response rates (RR) of up to 70% [ 2, 3].
Phase II studies investigating I-MIBG in patients with refractory or relapsed neuroblastoma have shown response rates in the range 0 – 56 % [ 2].
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Experiments with silvereyes and northern wheatears have shown responses indicating that the magnetic field can be used for navigation [32], [33].
In clinical trials, whilst patients from several tumor types have shown responses to MEK inhibitor monotherapy, other patients' tumors, particularly non-small cell lung cancers, are inherently resistant to MEK inhibition.
Most of these genes have shown responses to other viral diseases in salmon [ 9].
Many novel agents have shown responses in treated and untreated populations (Kerr, 2004).
Furthermore, many phytochemicals with different pharmacological properties have shown responses for the prevention or treatment of different tumors, e.g., flavones, flavanols, isoflavones, catechins, and taxanes [ 3- 7].
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