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Other reports have shown modification of VEGFR2 in response to various ROS-inducing agents, including H2O2 (Gonzalez-Pacheco et al, 2006), which is presumably increased in SOD2-deficient cell lines.
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These analyses have shown modifications as a function of molybdate concentration.
Our investigations (unpublished) have shown modifications at the level of the pinealocytes and an accumulation of calcium deposits in both the pineal organ and retina of aged shrews compared to young individuals.
47 Animal studies on the aging liver have shown modifications of the hepatic physiology which affect drug metabolism.
Studies carried out in our laboratory have shown modifications in the abundance of Oat5 protein in homogenates and in apical membranes from total renal tissue in different models of renal injury [ 13– 15].
Furthermore, it is possible that MR cells are key elements of these changes, since several studies have shown modifications to the MR machinery in the gill and skin epithelia in several fish species in response to manipulations of environmental [Ca2+] [ 48- 52].
Other results have shown the modification of a natural auroral arc and local spiral-like formation.
The numerical simulations of fluid flow have shown a modification of the axial filtration velocity profile with packing density.
Our previous studies have shown that modification of the stilbene backbone with the methylthio group may influence selectivity and inhibitory potency toward P450 isozymes.
Previous studies have shown that modification of HDS catalysts by acidic species, such as phosphorus, improves the activities of Mo/γ-Al2O3 catalysts [9, 10].
On the contrary, several reports have shown that modification of Notch by Fringe enhances Delta-mediated activation [37], [39], [42].
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