So far, the faceted crystals have shown encouraging improvement in the field of environment and energy applications.
Interestingly, some of the cytokines which have shown encouraging anti-tumor activity, including IFNs, IL-4, IL-12 and TNF-α, are endowed with anti-angiogenic or vasculotoxic effects, which may significantly contribute to local tumor control.
Both preclinical and clinical reports have shown encouraging prognostic and predictive power of FAZA-PET-based hypoxia imaging, particularly when used in conjunction with radiotherapy [4, 8, 9].
In the past, isolated findings have shown encouraging trends in a handful of states, but this is the first study -- according to Dr. Thomas R. Frieden, CDC director -- to show progress across the country.
The first HDACIs tested in clinical trials have shown encouraging anti-tumor effects, at dosages well-tolerated by patients.
All four agents have shown encouraging preliminary activity, and those that have been evaluated in larger patient populations appear to have encouraging safety profiles.
Additionally, soluble TGFβRII and betaglycan recombinant receptors, which compete for extracellular TGFβ, as well as inhibitors TGFβRI kinase activity have shown encouraging anti-metastatic results [ 84].
In several animal models, neutralizing anti-VEGF antibodies have shown encouraging inhibitory effects on solid tumour growth, ascites formation and metastatic dissemination.
New neoadjuvant chemoradiation regimens including drugs such as paclitaxel have shown encouraging complete response rates (29 39%) and R0 resection rates.
Extracellular Wnt inhibitors, including the secreted frizzled-related proteins, have been pursued as potential therapeutic agents, 25 and small molecular antagonists of the protein protein interaction between β-catenin and transcription TCFs have shown encouraging preclinical results.
To our knowledge, selective SYK inhibitors, such as PRT062607 (Portola/Biogen Idec), have shown encouraging preclinical data [ 19] but their potential efficacy in RA patients has not been evaluated.
