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Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity.
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Small molecule inhibitors of the APC/C substrates aurora A and aurora B kinases have shown antineoplastic activity in animal tumor models and several are currently in clinical trials [ 89, 128].
Additionally, the gall bladder shares a common embryonic origin with exocrine pancreas, where gemcitabine has shown antineoplastic effectiveness (Moore, 1996).
Subsequently resveratrol as a nontoxic agent has shown antineoplastic activity and very high efficacy in various cancer therapies [ 18– 20].
Essential oils from fruits of Monodora myristica, Xylopia aethiopica and Xylopia parviflora have shown acceptable antineoplastic potency, and might be investigated further in this regard.
Other esoteric methods have shown potential, too.
Vascular disrupting agents given as single agents have shown poor antineoplastic activity, whereas their combination with chemotherapy has yielded promising responses in preclinical models (Horsman and Siemann, 2006).
In vivo studies have shown that antineoplastic activities of metformin are more pronounced in mice receiving a high-energy diet associated with hyperinsulinemia and rapid tumor growth compared with mice receiving a control diet (38).
However, while the use of mycophenolate was associated with a reduced cancer incidence, probably because its administration is correlated to calcineurin inhibitor dose reduction, mTOR inhibitors have shown a direct antineoplastic effect.
Some members of the family of Casiopeínas have shown cytotoxic, genotoxic and antineoplastic activity both in in vitro and in vivo studies [3 5].
and studies have shown that TQ possesses antineoplastic properties [2], [3], [4].
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