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Histone 4 is the only nucleosomal subunit present as a single copy gene and thus its down-regulation could have severe implication on the nucleosomal assembly during the P. falciparum schizont stage.
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Even a restructuring would likely have severe implications on his 125-member staff.
The strength of a slope materials and groundwater depth (GWD) could have severe implications on the stability of the slope (Tables 11, 12, 13).
Without local capacity to continue assistance in the absence of the organization's local presence, the possibility for abrupt stoppage of assistance is great and may have severe implications on beneficiaries and future attempts at reinstating assistance.
However, termination of drug release from such a CRDDS at tdel and/or a declining drug input function towards the terminal phase of tdel from a first order kinetic CRDDS can have severe implications on plasma drug concentration and steady state fluctuations for a drug with very short half-life.
Moreover, it is clear that the Ebola outbreak will have severe implications on the economies in the region.
UNICEF's report shows that, even if children are not direct victims of family violence, witnessing the violence can have severe implications on children's development, health, their ability to learn or even their willingness to attend school.
Although we did not include the following as explicitly in our manuscript, we would like to point out that what might seem as minor technical differences between our and the Anisimov et al. (2015) study, can have severe implications for the study species and thus on the levels of conclusions that can be drawn (please also see the response to the first concern raised by Reviewer 1).
Changes in the shape, mechanical characteristics or the integrity of the erythrocyte has severe implications on the functionality of the cell, as can be seen in several dysfunctional states of the erythrocyte, whether it is environmentally induced, due to hereditary defects or diseased states [ 3].
"It's something that has severe implications on privacy and First Amendment rights and there is no basis to believe it improves security at all".
"If replicated in less specific systems, this could have severe implications for crop productivity".
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CEO of Professional Science Editing for Scientists @ prosciediting.com