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Indeed, the complexity of a model including both covariate by covariate interactions and time by covariate interactions, especially when covariates have several modalities, such as in our example (primary nephropathies), makes the model interpretation very difficult.
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It is crucial to note that many of these patients have had several modalities of treatment prior or after I-MIBG therapy, which could also increase the risk of haematological malignancies, but they were not shown to be significant factors during analysis of this subgroup of patients to predict the increased risk of the development of haematological malignancy.
Patients may have several life-support modalities withheld or withdrawn.
Conventional cancer treatment modalities have several limitations including lack of sufficient efficacy, serious untoward toxicity, as well as innate and acquired drug resistance.
We opted to systematically review the current evidence of axillary staging using MRI, since it appears to have several advantages over other imaging modalities, such as the lack of ionising radiation (compared to PET/CT) or less intra- and interobserver variation (common in ultrasound examinations).
Oligonucleotides, however, have several suboptimal properties as therapeutic modalities or chemical genetics probes of function, including poor cellular permeability and nonspecific stimulation of the immune system.
Despite the many advantages of antibodies as a drug modality, they have several limitations, chief amongst those being the high cost of manufacture.
Since the 1990s, there have emerged several modalities to treat uterine fibroids, including uterine artery embolization (UAE) and magnetic resonance-guided focused ultrasound (MRgFUS).
As the PC treatment alternatives described in our choice sets were very realistic, each treatment modality had several fixed attribute levels (i.e., one fixed attribute level for 'risk of other side effects', one fixed attribute level for 'frequency of PSA testing', and one fixed attribute level for 'treatment aim').
Multimodal neuroimaging has several distinct advantages over single modality neuroimaging, including improving both spatial and temporal resolution, finding the anatomical basis for functional connectivity, targeting disease biomarkers with high specificity and sensitivity, along with many new opportunities to improve brain research [109].
This sensor has several advantages for combining the two modalities.
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CEO of Professional Science Editing for Scientists @ prosciediting.com