Validation of such techniques has several difficulties.
Using the LOC metric also has several difficulties, for example, it is not a language independent metric.
There could be no doubt that firms participate in global sourcing so as to save manufacturing costs even though the global sourcing has several difficulties.
Although it is well known that variable selection has several difficulties (Sauerbrei, 1999; Harrell, 2001), these strategies are often required to derive a sensible, interpretable, and parsimonious model (Sauerbrei, 1999; Royston and Sauerbrei, 2008).
However, CCRT has several difficulties in terms of preserving the ovarian function, reducing late radiation-based adverse effects, and managing pelvic lesions which remain or recur after CCRT [ 18].
The workshop installed in a learning virtual environment (moodle) and has several difficulty levels.
Proxy-rated Qol instruments have several methodological difficulties.
E17:...we have several operational difficulties because the funding is in a single account belonging to the government, isn't it, belonging to the university; so, everything has to go out to tender, to a bid.
B&R bike tours have several levels of difficulty: 1A, 1B, 2, 3, the last being for people who like riding 100 klicks (kilometers) a day up the side of canyons.
However, these vaccines have several shortcomings, such as difficulties of in vitro culturing, biohazard risks, as well as loss of efficacy due to the genetic variations seen in many viruses.
