Often, these attempts have required modifications to the chemistry (e.g., use of alternative solvents or reduced temperatures) to reduce the pressures involved and avoid exceeding the limitations of the radiosynthesizers [8, 11 16].
In the approach selected, this extension has required modifications to the flow simulator (TOUGH2) and to the coupling scheme between the geomechanics and the flow sub-problems.
The motion, which would have required the modification of the Congo's new constitution (Loi fondamentale), was received by a parliament divided between Lumumba and Kasa-Vubu factions and no agreement could be reached.
While we share the reviewers' concern that one or more of the in vitro structures may not reflect functional complexes, we note that: All structures solved so far (including ours) have required some modification of the Rev-RRE system to enable structure determination, owing to the biochemical behavior of the system.
In previous studies of sequential administration of VEGF-targeted agents, overlapping toxicity profiles of these agents have resulted in high incidences of certain treatment-related AEs, such as hypertension, skin toxicities, fatigue and gastrointestinal toxicities, some of which have required dose modifications (Rini et al, 2008, 2011; Di Lorenzo et al, 2009; Garcia et al, 2010).
This would have required much less modification, but Major General Leslie R. Groves, Jr., the director of the Manhattan Project, and General Henry H. Arnold, the Chief of United States Army Air Forces (USAAF), wished to use an American plane, if this was at all possible.
Location scouts looked at North Carolina as a possibility, but found that sites that seemed appropriate for the film's requirements would have required extensive building, repairs, or modification, which would have inflated costs.
Mild: the adverse event was noticeable to the individual; it did not require modification of the dose but may have required additional therapy, such as paracetamol.
The KFI has required extensive modification for use in oncology because it was originally designed to assess comorbidity in diabetic patients.
Indeed, the transposition into French law of Directive 2001/20/CE, which relates to good clinical practice in the conduction of trials on drugs for human use, has required the modification of certain provisions that concern the protection of persons participating in biomedical research, in particular those provisions concerning the conditions for the authorization of biomedical research.
