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Indeed, a number of studies have reported differentially regulated miRNAs in diverse cancer types such as breast cancer [7], lung cancer [8], chronic lymphocytic leukemia [9], colon cancer [10], thyroid carcinomas [11], pancreatic cancer [12], head and neck cancer [5], prostate cancer [13], pituitary adenomas [14], and ovarian cancer [15] [18].
Other studies have reported differentially methylated genes between HP- and HP+ GC tissue [ 48, 69].
Whole transcriptome studies have reported differentially expressed genes after medium transfer from irradiated normal human diploid lung fibroblasts [ 23] and in normal human fibroblasts exposed to a small number of carbon ions targeted to defined sites in the culture [ 24].
Recent studies have reported differentially regulated miRNAs in diverse cancer types, such as breast cancer [ 5], lung cancer [ 6], prostate cancer [ 7], colon cancer [ 8], ovarian cancer [ 9] and head and neck cancer [ 10]. miRNAs are also implicated in a number of neurological disorders including Alzheimer's disease [ 11], multiple sclerosis [ 12] and schizophrenia [ 13].
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The majority of studies have reported differential DNA methylation of candidate genes in relation to diabetes and glycemic indices, but no overlap has been found between the differentially methylated CpGs sites in epigenome-wide association studies.
Some few studies have reported genes differentially regulated in scrapie and TSEs, mostly from brain tissues [ 21- 23].
Studies that have utilized currently available genome-wide profiling techniques have reported numerous differentially methylated genes in HCC, including tumor suppressor genes.
Previous studies of DNA methylation using the Illumina 27 K BeadChip methylation array have reported autosomal differentially methylated positions (DMPs) or CpG sites with varying methylation between males and females, providing evidence that it will be important to adjust for sex in analysis of methylation data [ 1– 6].
Many studies have reported finding more differentially expressed genes using HTS than using microarrays [ 30- 33].
In fact, many studies have reported that the genes differentially expressed in breast cancer cells are more inclined to be enriched on cytokine-cytokine receptor interaction pathway [ 39, 40].
Other studies have reported systematic screening of differentially expressed genes in the skin of mice with the Hr mutation, including analyses of gene expression in the skin of Hr N mice, another Hr-overexpressing mutant, and Hr tm1Cct, an Hr-loss-of-function mutant [ 7, 18].
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