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Numerous recent high profile publications have provided proofs of concept that RNA interference may be useful therapeutically.
During the long period of investigation, numerous experiments have been performed and have provided proofs of CSC occurrence.
25, 26 Consequently, transmission modeling is not commonplace, although research projects have provided proofs of principle models for VL transmission in Asia 31 and for canine leishmaniasis in Europe.
The above results have provided proofs of mechanism (ALDH inhibition after administration and in vivo) and principle (induction of aversion to alcohol) by the combined administration of Trp and the kynureninase inhibitor BSZ.
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Others have provided proof of family in the UK but to no avail.
If I had not already known it, the Q&A organised by Higgs would have provided proof, as it revealed the artist belittling his work and struggling to make the simplest decisions.
Not only did National Fuel then sue Mr Lee (successfully) for the return of the documents that might have provided proof, but it also persuaded a local court to ban him from ever repeating the accusations.
Phase I and II studies have provided proof of principle, and support the continuing clinical investigation of aflibercept.
Knockout and transgenic models have provided proof of concept that mutations in specific podocyte proteins mediate genetic forms of focal segmental glomerulosclerosis.
Though therapies using embryonic stem cells from SCNT embryos are not yet on the horizon for humans, scientists have provided proof of concept for these therapies in the mouse.
Although many studies have provided proof-of-principle that infectious diseases may result from various types of inborn errors of immunity, the genetic determinism of most infectious diseases in most patients remains unclear.
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