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These have provided a system to test the function of PfAMA1 by inserting specific mutations and through this added additional evidence that this protein is required for merozoite invasion (Leykauf et al., 2010).
Most recently, the knock-in models have provided a system with pathophysiological levels of JAK2V617F and have permitted higher-resolution studies of particular cell compartments (e.g. stem and progenitor cells).
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Taken together, through comparative transcriptome analysis and construction of a citrus gene coexpression analysis, we have provided a systems view of citrus response to the Ca. Liberibacter infection causing HLB.
"Nature has provided a system in which regulatory cells become increasingly potent but carry with them the seeds of their destruction," says Strom. "Overall, they did a fine job," says transplant immunologist Thomas Wekerle of the Medical University of Vienna, who wasn't involved with the research.
The formation of NHREC has provided a system for the regulation, capacity building and coordination of activities of various institutional review boards.
At some stage a group of wolves, who happened to be smaller and less threatening than most, developed a dependency on human groups, and may in return have provided a warning system.
Polytene chromosome spreads have provided a formidable system for visualization of MSL binding on the male X chromosome (Fig. 2).
The nonmethylated and methylated hairpin DNAs employed in this study have provided a model system that has permitted the analysis of the effects of cytidine methylation on single- and double-strand DNA breaks mediated by Fe·BLM.
Over the years, membrane-soluble peptides have provided a convenient model system to investigate the folding and assembly of integral membrane proteins.
The Drosophila imaginal wing discs have provided a suitable model system for the genetic and molecular analysis of the different pathway functions.
The evolution of the first PYHIN protein is likely to have provided a new effector system for combating the threats indicated by stray DNA within mammalian cells.
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