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The TSQM has been shown to be psychometrically robust and to have proven validity and reliability with Arabic patients [ 33, 34].
The interRAI functional assessment items used to create these scales have high reliability, have been used in a wide variety of applications, and have proven validity.
Additionally, trialists should consider using symptom severity outcome measures that have proven validity and reliability, such as visual analogue scales [ 35- 37], osteoarthritis specific outcome measures (e.g. WOMAC, Lequesne Index) [ 35- 38], and health-related quality of life instruments (e.g. Medical Outcomes Survey Short-Form 36) [ 35, 37, 38].
Candidate biomarkers in osteoarthritis should also have proven validity, reproducibility and predictive value, and there should be ample information on how they relate to processes in the joint and clinical endpoints (such as structural damage, pain or dysfunction and/or joint replacement).
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The instrument has been well used and has proven validity and reliability.
18 It has proven validity and reliability in both general public and patients with medical conditions.
It was developed in the Netherlands and has proven validity and reliability [ 36, 37].
The modality has proven validity in this setting, with sensitivity values ranging from 77% to 92% and specificities ranging from 89% to 100%.
The Gross Motor Function Measure (GMFM-66) allows a quantitative assessment of gross motor function in individuals with CP and has proven validity and reliability.
This self-report measure has proven validity, reliability, and psychometric capability for both general medical patients and depressed patients [ 3, 6, 26].
It has proven validity and it is appropriate for use in studies with a large sample size and studies focusing on patient-based assessments [ 26].
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