This methodology has proven relevant as its application resulted in the identification of new potential methylated genes [ 24, 25].
But it provides a simpler description of vertebrate anatomy, which has proven relevant and useful to studying gene expression patterns (e.g. it is used in the Prosite database) (Sigrist et al., 2010).
His words have proven more relevant over time.
Cellular models of HGPS and cellular senescence of fibroblasts have proven to be relevant models for organismal aging.
These cells are found predominantly in the upper dermis, whereas CD8+ cells have proven to be relevant during chronic phases and are found predominantly in the epidermis [ 21], although others have found a more early involvement of CD8+ T-cells in the development of psoriatic plaques [ 22].
Until further notice, for chronic back pain these determinants concern foremost the same objectives, target areas, contents and methods that have proven to be relevant or effective, respectively, in the institutional phase of rehabilitation as postulated in current recommendations and described above.
This system collects lists of genes that have proven to be relevant to three kinds of cardiovascular diseases—hypertension, obesity and diabetes, with the last disease specified as Type 1 or Type 2. It can be used to affirm the association of genes with these diseases and provides evidence for further studies.
Thus, the integration of genetic and epigenetic platforms seems only natural, since individually both types of platforms have proven to capture biologically relevant information.
Our intervention relies on models of Social Influence [ 23, 61] and Motivational Interviewing [ 22], which have proven effectiveness in prior relevant research [ 34, 62].
Packaging production and crop cultivation have proven to be the most relevant subsystems for all the studied products and impact categories.
