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The Bombyx mori actin 3C promoter and Drosophila ubiquitin promoter have proven active in a variety of insect species [ 13] and should be evaluated in Spodoptera insect cell culture as an alternative means to possibly improve transgene expression.
It is interesting to note that our reporter assays have not demonstrated promoter activity of the Juan-A 5'UTR in cell lines from three mosquito species, while 5'UTRs of mosquito non-LTRs from 3 non-LTR clades have proven active in all 3 lines (not shown).
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Stress-assisted grain boundary migration is a mechanism that has proven active in polycrystals but that relies on a limited number of models.
PABA/NO has proven active in several cancer models in vitro and in vivo, but its tendency to be metabolized via a variety of pathways, some that generate inactive metabolites and hydrolysis products, limits its potential as a drug.
The RKI has recently used the phrase "limited virucidal activity" ("active against enveloped viruses such as HIV, HBV, and HCV") to describe a preparation that has proven active against two representative enveloped viruses, vaccinia virus and bovine viral diarrhea virus (BVDV) [ 11].
Similarly, the results of this study should not be generalized to different subpopulations of breast cancer patients; weekly docetaxel has proven active and extremely well tolerated among elderly breast cancer patients, a population that would be at risk of toxicity with standard 3-weekly scheduling [ 30, 31].
CpG-oligodeoxynucleotides (ODN) are TLR9 ligands that have proven particularly active for immunotherapy of cancer and infectious and allergic diseases in animal models.
VWT and VMoT SCR catalysts have proven to be active in oxidation of chlorobenzenes, while, in the same reaction conditions, polychlorinated compounds formation, although in very low amount, limits the application of Pt alumina catalyst in chlorinated VOC combustion.
Water-soluble chitosan have proven to be active against Prevotella gingivalis (MIC = 0.31 mg/mL) and Fusobacterium nucleatum (0.08 mg/mL) [ 33].
In both the US and Western Europe, Ceftolozane/Tazobactam (C/T) have proven to be active against the majority of P.aeruginosa strains whereas resistance occured in more than 20% of commonly used antibiotics (Cubist: data on file).
Zinc complexes with neutral guanidine ligands have proven to be highly active initiators in the ROP of lactide [3, 4].
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