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Virtual surgical planning (VSP) with subsequent computer-aided design and manufacturing have proved efficacious in improving the efficiency and outcomes of a plethora of surgical modalities, including mandibular reconstruction and orthognathic surgery.
Broadly similar strategies have proved efficacious for a variety of other products 58.
In general, both routes have proved efficacious and are being routinely employed by stem cell researchers.
However, as yet no specific pharmacological therapies to target the underlying pathological processes have proved efficacious [ 9].
Also topical use of products containing eprinomectin, doramectin and moxidectin have proved efficacious in some treatments, but not in others [ 16, 10].
It is, thus, not surprising that JAK inhibitors have proved efficacious in animal models of arthritis [ 6, 7], and in clinics [ 8, 9].
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Although a few of them have shown limited efficiency in animal models or in small clinical studies, none of the currently available antioxidants have proven efficacious in a large-scale controlled study.
Many of these strategies have proven efficacious in the short term, but less successful in long-term weight loss and maintenance of that weight loss.
The cationic, ortho Mn III) N-alkylpyridylporphyrins (alkyl=ethyl, E, and n-hexyl, nHex) MnTE-2-PyP(5+) (AEOL10113, FBC-007) and MnTnHex-2-PyP(5+) have proven efficacious in numerous in vivo animal models of diseases having oxidative stress in common.
Biologic therapies have proven efficacious for patients with moderate-to-severe psoriasis.
Psychosocial interventions have proven efficacious for helping patients and families confront the many issues that arise during this difficult time.
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