Although L. major is pteridine- and purine-auxotroph, well-established folate biosynthesis inhibitors, such as methotrexate, have poor effect over the parasite survival.
the number of attacks per month exceeds two; attack medications have poor effect; the patient's quality of life is reduced considerably due to the migraine; frequent or very long-lasting cases of aura occur.
Prophylactic treatment should be considered [10] if the number of attacks per month exceeds two; attack medications have poor effect; the patient's quality of life is reduced considerably due to the migraine; frequent or very long-lasting cases of aura occur.
We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival (P = 0.009 and 0.035, respectively), and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival (P = 0.037 and 0.039, respectively).
There is little evidence in support of the fact that IFNβ-1b has poor effect on the resolution of inflammation.
Instead of lavishing money on the military and on the wealthy, which have poor multiplier effects, it's time to take those funds and put policies in place that will actually stimulate growth.
Short-acting barbiturates are commonly given intravenously; they have poor analgesic effects yet reasonable muscle relaxation.
Once obesity is established, therapeutic interventions are expensive and tend to have poor long-term effects.
They have poor data on the effects on immune function, for example, and there is considerable concern about the damage spaceflight causes to the eyes.
For the PET filament tow, the fibers from the middle layer tend to have poorer treatment effect than those from the top and the bottom layers in terms of surface roughness, wettability and surface chemical composition change.
