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They say they will implement £12bn of cuts to the welfare budget by 2018, but so far they have only explained about £2bn of those cuts.
So far I have only explained what might have led to the asymmetries, but what caused the left-right symmetry?
The effect of CB1 activity on cholesterol transport may be mediated through SRB1 or ABCG1 [46] To date, common variants in biological candidate genes have only explained a small fraction (typically less than 5%) of the variance in complex traits such as dyslipidemia [50], [51].
HDL is under tight genetic control (h2 up to ∼70%) [21], yet despite HDL's high heritability, even some of the most well powered GWAS studies have only explained a very small proportion of HDL variation using common SNPs [9], [12], [22].
Although environmental factors, mainly nutrition and UV-B radiation, have been considered major determinants of vitamin D status, they have only explained a modest proportion of the variation in serum 25-hydroxyvitamin D. We aimed to study the seasonal impact of genetic factors on serum 25-hydroxyvitamin D concentrations.
To date, published GWAS have only explained a small amount of the variance among lipid traits which are known to be influenced to different degrees by environmental factors.
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Study-specific potency estimates are highly heterogeneous, and current and previous efforts (e.g., Berman and Crump 2008a, 2008b; Hodgson and Darnton 2000; Lash et al. 1997) to explain inconsistent potency estimates have only partially explained their variance.
And, at the moment, the NDP have only really explained how they'll pay for part of it.
However, disease-causing functional defects have only been explained for a few genes (for example, NOD2, IL23R), which are also intimately tied to the microbiome by crucial roles in controlling microbial infiltration in the gut [ 26].
These advancements have not only explained the pathogenic mechanisms of L. monocytogenes, but have also laid a new foundation for the rational design of better small animal models in studying human infections caused by this pathogen.
Candidate gene based association studies have similarly only explained a small percentage of the genetic component of ADHD and the first GWAS did not report many significant findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com