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Since strains A-2A and A-4 were almost completely rescued by ferrous iron, they appeared to have no defects in their systems for direct iron uptake.
The abundant proteoglycan, aggrecan, is resorbed from growth plate cartilage during endochondral bone ossification, yet mice with genetically-ablated aggrecan-degrading activity have no defects in bone formation.
However, synapsis mutants generally have no defects in SPO-11-mediated DSB induction, and the majority of DSBs are ultimately repaired.
For example, progeria patients have no defects in their mental and intellectual abilities, which suggests that the brain may be protected from, and/or insensitive to, and/or unaffected by, the expression of the progeria mutation.
Before the NOR tests, open field studies showed that FDDKI mice have no defects in habituation, sedation, risk assessment and anxiety-like behaviour in novel environments, as previously reported (Tamayev et al, 2010b).
As previously reported (Tamayev et al, 2010b), open field studies showed that FDDKI mice have no defects in habituation, sedation, risk assessment and anxiety-like behaviour in novel environments.
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This strongly suggests that age3Δ cells have no defect in ergosterol biosynthesis, a process that is targeted by azoles.
Loss-of-function genetic studies revealed that unlike the Drosophila neur mutants, Neur1−/− mice have no defect in neurogenesis and embryonic development, possibly due to a functional overlap with Neur2 [17], [17].
Mutants lacking both scaffolds have no defect in total surface receptors (assessed by muscimol-activated currents).
The importance of this mechanism requires clarification, however, because p62/SQSTM1 null cells have no defect in Parkin-mediated mitophagy (17, 18).
(B ) 2-day-old sir-2.1 0) sir-2.1 0e no defect in turning behavior, (C ) sensing the vulva of the hermalesodite and (D ) staying at thaveulva.
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