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This sort of movement-building is arduous, of course, but Roemer can look to the example of Ron Paul, whose own failed runs for the White House have nevertheless led to an impressive grassroots movement, which is getting footsoldiers trained in the peculiarities of the primary process and helping like-minded candidates get nominated and elected.
This is of crucial importance to drug discovery and testing, but practical constraints particularly the desire for convenient readouts—have nevertheless led most assays to be undertaken in conditions that are far removed from their native or intended physiological contexts.
Although the absence of detectable nuclear β-catenin in adenomas could also reflect the sensitivity of the detection methods, the observations have nevertheless led to the identification of additional steps required for nuclear translocation of β-catenin, including activation of Ras and Rac1 (Phelps et al., 2009b; Zhu et al., 2012).
The marked increase in the national [ 2] and international [ 21] public's and media's interest in issues of sexual abuse have nevertheless led to increased efforts by more and more nations (such as Germany, England, South Africa, Australia or the Philippines) which are attempting to actively pursue policies against sexual abuse [ 22- 24].
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Obama's lead in Pennsylvania has often been narrow, but he has nevertheless led by some margin in the state's last 22 polls.
The early success of The Dark Knight Rises has nevertheless led to talk of sequels and followups, despite Nolan's assertion that this will be his last Batman film.
Though the push for such rights has moved at a glacial pace, the implementation of various reforms this year has nevertheless led many observers to believe that it is critical for the ruling family to avoid liberalizing society in a way that could drive more conservative-minded Saudis to extremism, threatening the country's security.
The Braves, who have a solid division lead, have nevertheless created the same ratio of change in recent weeks.
Ms. Manina, 36, whose tastes lean more toward R & B stars like Jaheim than classic rock stars, like Johnny Winter, had nevertheless ridden the Led Zeppelin coaster, which, she said, "shook my brain".
That fight was resolved just hours before the country could have defaulted on its debt, but nevertheless led to ratings agency Standard & Poor's downgrading the US for the first time ever.
England had nevertheless earned a lead of 42 and looked well placed to put Pakistan under pressure once Anderson enticed Taufeeq Umar to offer an edge to Strauss at slip.
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