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However, it was previously noted that self-interacting proteins tend to have more interacting partners (higher connectivity) than non-self-interacting genes [ 9] and we confirm this for our dataset.
We applied simple logistic regression [ 28, 29] to measure the proportion of genes encoding self-interacting proteins over all genes with a particular number of interacting partners (degree) k, and in accordance with Ispolatov and colleagues [ 9] we found that self-interacting genes tend to have more interacting partners in general (not shown).
This result is almost identical to that of the raw Ito PPI network, indicating that the Y2H method does not bias essential proteins to have more interacting partners.
A possible biological explanation of the relationship between τ and ω is increased pleiotropy: Proteins that are expressed in many tissues may tend to have more interacting partners, which lead to more constraints on the function and/or structure of the protein, and a corresponding reduction in evolutionary rate (Pál et al. 2006).
Liang and Li [ 72] found that multiple miRNA-regulated proteins have more interacting neighbours in a PPI network.
When candidate genes have more interacting partners in a network and are closer to other known disease genes, RW may perform better than the other methods.
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On the other side, CHGB has more interacting partners than IL6 (45 vs. 6 connections).
"We have more people interacting with content than in the history of the magazine.
Google+ has impressive functionality and a nice user experience for photos, but is still fighting an uphill battle against Instagram, Flickr, Facebook and others, many of whom have more users interacting with more photos.
Indeed, there is evidence that because low-income whites have more experience interacting with minority students in high school, they are more likely than other whites to engage with students of other races during college.
Briefly, ICN determines that these genes are more likely to belong to the same functional module if two genes have more shared interacting genes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com