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In mice, we have maximal control over dosing and are assured of treatment compliance; in humans, neither of these is true.
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The dependence of TCA cycle activity on calcium is sigmoidal 104, which means that the cell has maximal control over this activity when [Ca2+]matrix is in the steeply rising part of the sigmoid curve, as indicated in Fig. 4A.
Highly coordinated interactions among these members are needed to ensure maximal control over these survival pathways.
The combined treatment with the Rho-kinase inhibitor and the corticosteroid provided maximal control over the remodeling response and inflammation in the airways and parenchyma.
At the same time, we avoided a more realistic, and therefore more complex, environment in order to retain maximal control over the experimental variables.
That is operationally super lean and that has maximal impact on bottom line metrics.
Especially in those cases where product formation is not correlated with maximal growth, it is advantageous to have full control over the specific growth rate.
You have complete control over that.
Officials have tightened control over monasteries.
"Everything else, we have no control over.
"I have no control over that".
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