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Clinically approved antiangiogenic anticancer agents primarily target the VEGF pathway and have many limitations, such as increased resistance, toxicity, secondary metastases, and limited efficacy in certain cancer types, highlighting the need for novel agents targeting alternative pathways.
"Those who come to mind have many limitations.
So, the diagnostic distribution described here may have many limitations.
Even we can say that but we have many limitations in this work.
All presented localization algorithms have superiorities but also have many limitations.
But the static nodes have many limitations and cannot meet the requirement of actual application.
However, SMPs have many limitations and weaknesses that are exposed in engineering applications.
Currently available techniques to diagnose indeterminate biliary lesions have many limitations.
Although there exist enormous research efforts on grid-based collaboration technologies, most of them have many limitations.
However, current methods for the synthesis of these graphenes have many limitations, including the use of metal catalyst.
Although various physicochemical methods have been used to remove these compounds from our environment, they have many limitations.
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