Without this feature, unfortunately not available on a large scale, visually impaired users (VIU) have major difficulties in taking the best benefit of television contents.
MSF did, in fact, have major difficulties with the Ministry of Health in the last quarter of 2009 over a MSF communication that offended the ministry and nearly ended with the organization being expelled.
For example, he has major difficulty to identify and separate functions, perform actions in logical sequences, dial a telephone number, choose a correct command, identify information, and respond adequately when he makes a call with his cell phone (see Table 2).
Lawmakers and other space experts on Capitol Hill, however, said it was no secret that NASA has had major difficulties.
Dmrt3−/− mice, but not control mice (wild-type littermates), had major difficulties running at higher velocities (Fig. 2b and Supplementary Movie 3).
He added that "this is a substitute for commercial paper, and right now companies are having major difficulties rolling over commercial paper" — issuing short-term debt to finance their operations.
"Important contracts are being taken elsewhere, and we are being left with a contract that has major difficulties," said Harry Knowles, chief executive of a business lobby group called Furness Enterprise.
A retired senior C.I.A. official, one of many who left the agency recently, told me that he was familiar with the assessments, and confirmed that Iran is known to be having major difficulties in its weapons work.
We also genotyped 61 horses from one racing camp in a blind test; two of these had major difficulties in sustaining trot at high speed (Supplementary Fig. 1a, b and Supplementary Movie 1) and were heterozygous C/A, whereas all others were homozygous A/A (P = 0.0005).
