Sentence examples for have low affinity for from inspiring English sources

The bacterial family is subdivided into type I and type II1; type I enzymes are cytosolic, expressed constitutively and have low affinity for L-Asn, resulting in non-therapeutic applications, while type II enzymes are restricted in the periplasmic space, with induced expression during anaerobiosis, have high affinity for L-Asn and present antitumor activity2,3.

However, the C-terminal region of GmGT-2A or GmGT-2B appeared to have low affinity for the D1 element.

Others working on assessing performance of prediction methods in the yeast model organism have previously hypothesized that conservation-based methods might be more sensitive than PWM scanning and better at detecting motifs of binding sites that have low affinity for the transcription factor [14].

Two peptides that have low affinity for a target protein are then linked together to improve the binding affinity of the construct, a well-known technique to create high affinity ligands from two low affinity ligands [15], [16], [17], [18], [19].

These polar peptides have low affinity for a C18 column and, thus, often elute in the void volume.

Other PCB congeners have low affinity for the Ah receptor, and operate by non-Ah receptor mechanisms.

The ectodomains of interacting membrane-bound proteins, when expressed as recombinant soluble molecules, often have low affinities for each other, hampering studies of their interaction.

Unlike structured proteins, most unstructured proteins have low affinities for their partners [ 42, 45- 47].

Both quetiapine and the SGA prototype – clozapine – have low affinities for the D2 receptor and do not reach receptor occupancies corresponding to the therapeutic window at clinical doses [ 31, 32].

Although the OH-PCBs have low affinities for both α and β estrogen receptors, some OH-PCBs are strikingly potent inhibitors of human estrogen sulfotransferase (SULT1E1), with sub-nanomolar concentrations that produced 50% inhibition (IC50) (Kester et al. 2000).

Most cells are selectively adhered on micro-structured silica particles, while a flat surface has low affinity for the cells.