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If selection against TEs is primarily mediated by these ectopic events, then selfing species are predicted to have less efficacious selection and higher TE copy numbers than outcrossing species.
The prevailing view that endosymbionts have less efficacious selection, resulting from reduced effective population sizes (Moran 1996; Andersson and Kurland 1998; Woolfit and Bromham 2003; Fares et al. 2004), fits well with some features of Hodgkinia genome, in particular with its tiny size and overall rapid rate of sequence evolution.
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94 Data from the ENESTnd study confirmed that a lower dose of nilotinib (600 mg daily) was as efficacious, may have less toxicity, and could be more cost-effective.
Western medicine was seen as efficacious, but its physicians were seen to have less time, listen less well and were more difficult to consult.
One plausible explanation as to why isoniazid may have been less efficacious in endemic regions is reinfection of the children with a different strain of Mycobacterium tuberculosis.
Chloroquine (CQ) plus SP has been less efficacious than AQ+SP in trials in Africa owing to widespread CQ resistance.
With respect to the effects on the adrenal gland at equally efficacious doses (ED50), ciclesonide had less severe side effects than fluticasone.
All other drugs had less than 0.10 probability of being most efficacious.
Intermittent pneumatic compression pumps (sural or plantar) are highly efficacious and increase the action of anticoagulants, although their management has less compliance from nurses and patients [1].
Moreover, the connections women do have tend to be less efficacious: Men's networks provide more informal help than women's do, and men are more likely to have mentors who help them get promoted.
These treatments shown to be less efficacious have then lost favor in the marketplace.
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CEO of Professional Science Editing for Scientists @ prosciediting.com