Because of azithromycin's safety profile, several studies have investigated modifications to the drug with a view to lowering the IC50 of short-term treatment (1 cycle of growth) to the low nanomolar range [ 42– 42].
Few studies have investigated effect modification by age, but there is some support of this phenomenon when comparing people with and without SMI [ 3, 13].
In addition to ubiquitination, two recent different studies have investigated the modification of ANXA1 through small ubiquitin-like modifiers (SUMO) in a mouse model.
Other studies have investigated effect modification by gender in relation to the association between traffic noise and BP and hypertension, but the results are inconclusive, as some studies suggests no difference [ 7, 10], some suggest strongest association among men [ 9, 11, 20] whereas others find strongest associations among women [ 8, 40].
As such, we have investigated the synthetic modification of Dz10 23 with a guanidinium group, a functionality that reduces the anionic nature and can potentially enhance the membrane permeability of oligonucleotides.
HPV has been associated with tumorigenesis, and many studies have investigated HPV-related modification of the immune system to establish infection.
We have investigated the histone modification pattern of the genes involved in alcohol metabolism and alcohol-related liver disease in the patient and control.
We have investigated the co-modification occurring in neighboring genes in the S. cerevisiae genome, and examined the relationship between co-modification, coexpression and co-function in neighboring gene pairs.
We have investigated how minor modifications of hit compound acyl Gly-L-Ala-D-Glu derivative I modulate the molecular recognition by NOD2.
Earlier studies have investigated various surface modifications of nanoparticles with active ligands to achieve further accumulation of nanoparticles in tumor cells, which is commonly referred to as active targeting and can remarkably enhance efficiency of specific endocytosis.
