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MB clade 7 viruses accounted for 34 viral sequences in our data set, and 52.9% (18/34) required hospitalization, peaking in November during wave 2. Such intensified regional sampling may have introduced confounding bias in our severity analysis.
A potential study weakness is the lack of random assignment of beta-blocker use, which may have introduced confounding.
Given the strong association between TDF use and HBsAg + status, this may also have introduced confounding by indication.
Intake of hormonal drugs, especially by women, was not assessed in this study and could also have introduced confounding.
However, there was a very high correlation in the mines, between radon and exposure to γ-radiation, which could have introduced confounding bias.
Further, those with cognitive impairment may have been less accurate in their recall and may have introduced confounding variation into the analysis.
However the multiple logistic model fitted the data poorly and the use of APACHE II to assess severity of illness would have introduced confounding.
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In any case, not adjusting for any potential differences in the socio-economic status of the children might have introduced uncontrolled confounding.
The self-reported screen time questionnaire without classification of different screen modalities made rough estimates of the independent variable, and the lack of information of non-screen-based sedentary behaviour may have introduced residual confounding.
One possible explanation is that some within-subject factors could have introduced additional confounding in the opposite direction of the confounders in the nested case-control analysis.
This might have introduced different confounding factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com