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Consequently, vertebrates should have increased requirements for suppression of rogue cell growth.
They have increased requirements for these minerals in order to ensure adequate postnatal skeletal growth.
One clinically important, but often overlooked, cardiovascular consequence is that diabetic and obese patients have increased requirements for surgical treatments.
It is proposed that certain proteins, such as various kinases and multimeric protein complexes, have increased requirements for the cellular protein folding apparatus, and hence they are more susceptible to misfolding than others.
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Patients in the influenza group presented more often with lower respiratory infection (100 vs. 73%, p = 0.135) and had increased requirement for mechanical ventilation on admission to the ICU (96 vs. 68%, p = 0.022).
Patients who have sustained traumatic brain injury (TBI) have increased nutritional requirements yet are often unable to eat normally, and adequate nutritional therapy is needed to optimise recovery.
Patients suffering from severe sepsis often have increased fluid requirements, which in itself may contribute to recurrent ACS [ 6].
Adenylate kinase expression was upregulated in wild-type cultures compared with csgD mutant cultures, suggesting that cells living in biofilm have increased ATP requirements.
In comparison with non-infected children, HIV-infected children are likely to have increased nutritional requirements, poor appetite and reduced intake due to illness and socioeconomic factors [ 16].
45– 47 Although older people who exercise have increased protein requirements, studies investigating whether nutritional supplementation in combination with resistance training can augment muscle strength gains in older people have yielded inconsistent results.
However, Drummond et al (2007) have aptly asked 'why have incentives to develop (orphan) drugs if they will later be judged by criteria on which they are doomed to fail?' During the last half-century governments and agencies across the world have increased their requirements for assuring the safety and efficacy of medicines.
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