So even though these are in vitro studies on a cell line, the results may have implications for actions of MTX in treated patients.
These novel results may also have implications for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Action in Diabetes and Vascular Disease Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) studies, in which intensive glucose-lowering therapy also failed to reduce CVD events.
On the other hand, FOXO3a and FOXM1 may cooperate to regulate ERα gene transcription in breast cancer cells [35], and this may have implications for the action of estrogens and anti-estrogens in cancer development and treatment.
Formally, rules of engagement refer to the orders issued by a competent military authority that delineate when, where, how, and against whom military force may be used, and they have implications for what actions soldiers may take on their own authority and what directives may be issued by a commanding officer.
These different configurations of risk and benefit - and the degree of uncertainty attached to these - have implications for the required actions of risk communicators, for example in terms of the required speed of response or the degree of required consumer involvement.
The association between lead exposure and LINE-1 DNA methylation may have implications for the mechanisms of action of lead on health outcomes, and also suggests that changes in DNA methylation may represent a biomarker of past lead exposure.
These data may have implications for the many important actions of estrogen in the adult and developing ovine brain.
These findings have implications for understanding the mechanism of action in IVIG resistance, and possibly for development of novel therapeutics.
Similar results with HUVECs have implications for understanding selenium's mechanisms of action as an anti-angiogenic agent.
On the weaker reading, the principles that regulate state action might have implications for what individuals should do in their private as well as public roles and might partially determine the standards regulating individual conduct.
These findings have implications for understanding the mechanism(s) of action of these phytochemical cancer prevention agents.
