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Yet, only 14 of the 40 BCD genes are expressed in liver, and these 14 have higher functional similarity values in all three categories: bp BCD, liver) = 0.44, mf BCD, liver) = 0.63, and cc BCD, liver) = 0.91, suggesting that the disease genes excluded by tissue specificity are those whose functional relatedness is smaller.
Have we not learned from various studies that women have higher functional aptitudes than men in specific areas of learning?
The biclusters generated in this manner also tend to have higher functional enrichments than those generated over the total expression dataset.
The genome design hypothesis predicted that the genes with intermediate expression breadths may have higher functional and regulatory complexity, and have larger intron length and protein length [ 17].
Again, gender should be considered, as previous studies have reported gender differences in functional disability, with elderly women reported to have higher functional disability than elderly men [ 80].
Furthermore, the enzymes in inhibiting pairs whose two members are RLEs have higher functional links than those in all the inhibiting pairs where only inhibitor providers are RLEs (p value <0.05, unequal t test) except in Mouse.
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Note that 0 ≤ FR t) ≤ 1. TF t would have high functional redundancy if there exists another TF q whose functions are highly similar to the functions of TF t.
The analysis also revealed a complex landscape of variation and function, with a few SNPs likely to have high functional significance but with most having little effect.
Furthermore, the predicted complexes have high functional homogeneity.
In several cases, enzymes predicted by network analysis to have high functional association have very little similarity in database annotations.
We have identified a subset of protein isoforms which appear to have high functional significance, particularly in regulation.
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