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Genetic polymorphisms have been identified and characterised in the aromatase gene and may have functional influences on the interaction between the enzyme protein, its substrate and inhibitors [ 47].
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This notion may have functional implications in the influence that mature and immature neurons could have on CA3 (Rangel et al., 2013).
The direct, hypothesis-driven approach is to investigate single nucleotide polymorphisms (SNPs), which are thought to have functional effects and thus influence directly the traits under study (Tabor et al, 2002).
They may have functional impairment.
Second, they have functional consequences.
The present dissociation between effects of core and shell lesions implies competing effects of amphetamine acting in different subregions of the NAc, which have also previously been characterized as having competing functional influences in the latent inhibition paradigm (Weiner, 2003).
Histone modifications have long been thought to have a functional influence on the regulation of transcription.
Next we aimed to determine whether bic 155 expression in DCs has functional significance and can influence the activation of antigen-specific T cells in vivo.
As described above, approaches such as the one used in RegulomeDB integrate published epigenomic datasets from multiple cell lines to indicate which SNPs are likely to have a functional influence.
Rather, most basic research in aging to date has focused on modifying a molecular target that is suspected of having a functional influence, and/or assessing biochemical and histopathological changes within the animals being subjected to intervention.
"It has functional limitations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com