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Aside from resolving the evolutionary history of the RLN1 and RLN2 paralogs our results have functional implications as well.
This recombination event may also have functional implications, as FIV Ple subtype E env has structural features more similar to pathogenic FIV Fca.
This finding may have functional implications as specific inhibitors of the interactions between c-Cbl and RTK have been recently identified.
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The increased dynamics of the α-helices, which face the DNA duplex in the PCNA-loaded form, relative to the outer β-sheet layer has functional implications as well concerning the sliding of DNA through the hole of the ring.
The small increase in expression in IRF9-/ B cells has functional implications as IFN-α-treated IRF9-/ B cells secreted significantly more IL-6 versus untreated IRF9-/ B cells in response to a TLR7 agonist [ 32], whereas virtually no IL-6 was secreted by IFNAR2-/ B cells in response to a TLR7 agonist, regardless of whether they were treated with IFN-α.
Critically short telomeres are assumed to have functional implications, such as the induction of cellular senescence, which is characterized by the expression of specific markers of aging and the inability of the cell to divide further [ 2].
A non-coding RNA gene with antisense complementarity to both grn1 and grn2 was identified which may have functional implications with respect to gene dosage, as well as in restricting the formation of the chimeric form of progranulin.
The re shaping of overlap in responses in the cortex may have functional implications for disorders such as focal hand dystonia [45].
This observation might have functional implications.
Our results might have functional implications within neural networks.
Perceptual changes also have functional implications.
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