'have functional impact' is correct and usable in written English.
You can use this phrase to refer to the outcome of changes that have been implemented. For example, "The new regulations are expected to have a functional impact on the local economy."
Although these relatively common (1 5% frequency) variants were computationally predicted to be functionally benign (22), our experimental data provide molecular evidence that they could have functional impact in cellular signaling regulation as well.
The balance impairment may have functional impact and it might be addressed with proper clinical interventions.
Because pertussis vaccines may modulate the balance between Th1 and Th2 immunity [22], we further screened the biomedical literature until October 2005 for SNPs within the candidate genes known to have functional impact on, or to be associated with Th2 diseases, notably asthma and atopy.
We then determined whether the two SNPs in regulatory regions, rs11636687 and rs28668016, might have functional impact.
Several variations leading to AASs in well-known driver genes do not have functional impact, for example in TP53 [ 6].
However, the two SNVs were far apart from one another and not predicted to have functional impact.
Although we focused on only six selected "putatively functional" coding variants, our biochemical investigation can be a useful initial step to find pol ι variations that have functional impacts and understanding their mechanistic implications.
Considering the SNPs may have functional impacts on gene expression, the expression Quantitative Trait Loci (eQTL) approach has been proposed and commonly used to facilitate the identification of associations between intergenic SNPs and traits [ 18- 20].
An insertion/deletion polymorphism in the promoter region of the SLC6A4 gene, termed 5-HTTLPR [22, 23] has functional impact on the synaptic clearing of serotonin [24].
We hope that our proposed approach can be used to discover mutations having functional impact.
Also, if this change has functional impact, our subjects (65 and 70 years, both asymptomatic) would be compound-heterozygotes for AIP mutations, whereas AIP knockout mice are not viable (they die at embryonic age e10.5 e14.5 due to cardiac malformations) [ Lin et al., 2007], thus suggesting this change has no functional impact.
