Sentence examples for have functional effects from inspiring English sources

These findings suggest that RIC may have functional effects on myocardial contractile function [ 1].

However, a second hypothesis is that because conserved regions are indeed likely to have important functions, variants that persist within these regions are actually those that are less likely to have functional effects, as variants that impact function are likely to reduce fitness and be subjected to negative selection pressure.

Although several of the SNPs, investigated in this study have been shown to have functional effects on gene expression or protein function, they may not themselves be the causal variant, but instead representative of the causal allele through linkage disequilibrium [52].

Literature search regarding functional data and family co-segregation revealed that 19 of the 33 identified LQTS-associated variants have been investigated functionally and 16 of these did have functional effects, but there was a striking lack of data regarding family co-segregation (Table 1 and Supplementary Table).

In silico analysis of the p.P49L mutation suggested that it could have functional effects.

Building on this, we tested whether common LPA species present in blood (16:0, 18 1, and 18 2) have functional effects on the carotid body output using an en bloc perfused carotid body preparation (Fig. 1c 33,38.

Other polymorphisms of the vitamin D receptor gene, such as the restriction site Fok I and the binding site for Cdx2, have functional effects, either on vitamin D receptor mRNA synthesis or its stability, with final consequences on the quantity and/or function of vitamin D receptor protein.

It is thus likely that this result is caused by linkage to a nearby rare SNP that does have functional effects.

Bovine milk contains cytokines like IL-10 that can have functional effects on immunological structures in the gut mucosa.

Hence, all genes at the IFIH1 locus may be interesting potential candidates in the etiology of T1D even though nsSNPs are more likely to have functional effects.

Several single nucleotide polymorphisms within genes which comprise the fibrinolytic system have been shown to have functional effects on the rate of blood clot degradation.